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Topical medicines work on the surface of the skin and the medication does not reach the bloodstream. This means that a topical product acts locally. On the other hand, transdermal medication penetrates the skin and enters the blood, thereby allowing the effects on the whole body through distribution of medicine via the bloodstream. An example of a topical medicine is hydrocortisone ointment used to treat skin rashes. The ointment containing the medicine is spread over the rash and works locally. A transdermal nitroglycerin patch used to treat heart or chest pain is placed on the skin to relieve the pain. In this example, the medicine is applied to the skin, but passes through and enters the blood where it migrates to the heart and the rest of the body. Topical medications can be creams, ointments, liquids, lotions, gels, sprays, foams, powders, and patches. Transdermal medications can come in gels, paste, and patches.